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KMID : 0545120160260122192
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 12 p.2192 ~ p.2198
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Cloning and Characterization of the IgA Fc Receptor from Swine
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Chen Yu Mei
Liu Yun Chao
Zhang Gai Ping
Feng Hua
Ji Peng Chao
Wang Guo Qiang
Liu Chang
Song Ya Peng
Su Yun Fang
Qiao Song Lin
Wang Ai Ping
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Abstract
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The myeloid-specific IgA Fc receptor (FcαR) is a cell surface molecule on immunocytes that provides a fundamental connection between humoral and cellular immunity. In this study, the full-length cDNA sequence of swine FcαRI (swFcαRI) was isolated and characterized and found to contain a 792-base-pair open reading frame, encoding a 264-amino-acid transmembrane glycoprotein with a predicted molecular mass of 29.4 kDa. The swFcαRI shares high amino acid sequence homology (>50%) with its counterparts from cattle, seal, and horse. Rosetting analysis confirmed that COS-7 cells transfected with an swFcαRI expression plasmid was able to combine with chicken erythrocytes sensitized with porcine IgA, but not IgG.
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KEYWORD
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Swine, IgA Fc receptor, FcαRI
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